NFATc4 is negatively regulated in miR-133a-mediated cardiomyocyte hypertrophic repression

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NFATc4 is negatively regulated in miR-133a-mediated cardiomyocyte hypertrophic repression.

Activation of NFAT (nuclear factor of activated T cells)-mediated hypertrophic signaling is a major regulatory response to hypertrophic stimuli. A recent study unveiled potential regulatory roles for microRNA-133a (miR-133a) in cardiac hypertrophy. To date, however, no connection has been made between miR-133a and NFAT signaling. In this study, we determined that NFATc4, a hypertrophy-associate...

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ژورنال

عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology

سال: 2010

ISSN: 0363-6135,1522-1539

DOI: 10.1152/ajpheart.00592.2009